HELP!!! Regarding the issue of being unable to simulate flow given multiple rock types~THX!

I am currently using TOUGHREACT V3 software and ECO2N module for flow simulation. When all the first domain is given in ELEME, the simulation is successful; When first & second domain are givenin ELEME, The simulation time is long and there is no result. In addition, when the first domain is given in ELEME, the flow simulation is successful under the conditions of 20MPa and 20 ℃, but it fails under the conditions of 1.5MPa and 20 ℃.THX!